Post by skyship on Jun 7, 2009 0:33:53 GMT -5
some references: G protein nano machine
www.nature.com/nature/journal/v379/n6563/abs/379297a0.html
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translocase nanomachine:
Bacterial protein secretion through
the translocase nanomachine
ecoserver.imbb.forth.gr/pdf/2007PapanikouNRM.pdf
============================
Biomedical Detectives:
By investigating stretches of RNA that scientists once thought to be simply junk, Anna Marie Pyle has discovered a treasure chest of biological information that may shed light on humans' evolutionary past. Pyle is an expert on RNA splicing, specifically the role Group II introns play in triggering key RNA reactions.
Pyle explains that RNA introns were once viewed as a sort of garbage surrounding exons, which carry out the key role of translating RNA into proteins that carry out all of life's functions. However, certain introns themselves fold into unique structures that are crucial to stitching together RNA — a process that is shared by most organisms and goes deep into evolutionary history.
The work on RNA structure has led her into the study of DExH/D proteins, which are protein nanomachines that remodel RNA molecules and play a role in RNA metabolism and viral replication.
===========================
Chief of Infectious Diseases, the Waldemar Von Zedtwitz Professor of Medicine, and Professor of Microbial Pathogenesis and of Epidemiology and Public Health
Just a few miles from where Lyme disease was discovered in the 1970s, Dr. Erol Fikrig has become an expert on the life cycle of the bacterium that causes the tick-borne disease.
It was Fikrig's lab that discovered the Lyme disease bacterium can actually induce a tick to produce more saliva when it bites its host; this saliva contains a protein that helps the disease bacterium avoid attack by the host's immune system. This observation has led to a new strategy to combat vector-borne diseases. Instead of targeting the organism itself, says Fikrig, perhaps scientists can attack those things in the environment that pathogens need to survive.
In addition to Lyme disease, Fikrig's lab studies another tick-borne disease, human granulocytic anaplasmosis, and an emerging mosquito-borne agent, West Nile virus.
======
opa.yale.edu/news/article.aspx?id=6235
skyship
www.nature.com/nature/journal/v379/n6563/abs/379297a0.html
=========================
translocase nanomachine:
Bacterial protein secretion through
the translocase nanomachine
ecoserver.imbb.forth.gr/pdf/2007PapanikouNRM.pdf
============================
Biomedical Detectives:
By investigating stretches of RNA that scientists once thought to be simply junk, Anna Marie Pyle has discovered a treasure chest of biological information that may shed light on humans' evolutionary past. Pyle is an expert on RNA splicing, specifically the role Group II introns play in triggering key RNA reactions.
Pyle explains that RNA introns were once viewed as a sort of garbage surrounding exons, which carry out the key role of translating RNA into proteins that carry out all of life's functions. However, certain introns themselves fold into unique structures that are crucial to stitching together RNA — a process that is shared by most organisms and goes deep into evolutionary history.
The work on RNA structure has led her into the study of DExH/D proteins, which are protein nanomachines that remodel RNA molecules and play a role in RNA metabolism and viral replication.
===========================
Chief of Infectious Diseases, the Waldemar Von Zedtwitz Professor of Medicine, and Professor of Microbial Pathogenesis and of Epidemiology and Public Health
Just a few miles from where Lyme disease was discovered in the 1970s, Dr. Erol Fikrig has become an expert on the life cycle of the bacterium that causes the tick-borne disease.
It was Fikrig's lab that discovered the Lyme disease bacterium can actually induce a tick to produce more saliva when it bites its host; this saliva contains a protein that helps the disease bacterium avoid attack by the host's immune system. This observation has led to a new strategy to combat vector-borne diseases. Instead of targeting the organism itself, says Fikrig, perhaps scientists can attack those things in the environment that pathogens need to survive.
In addition to Lyme disease, Fikrig's lab studies another tick-borne disease, human granulocytic anaplasmosis, and an emerging mosquito-borne agent, West Nile virus.
======
opa.yale.edu/news/article.aspx?id=6235
skyship