Post by skyship on Jul 9, 2009 15:08:51 GMT -5
In Morgellons there appears to be contacts or jolts from
certain areas of the body to others and appears that
the lesions and their contents signal to other lesions
and contents, fibers, neurons etc.
Here is a report that mentions transphophorylation.
===================
Analysis of the TGF-beta Receptor Signal Transduction Pathways and the TGE-beta Receptor Kinases
Authors: Kunxin Luo; WHITEHEAD INST FOR BIOMEDICAL RESEARCH CAMBRIDGE MA
Abstract: The principal goal of this project is to understand the transforming growth factor-Beta (TGF Beta) receptor signal transduction pathways and the molecular mechanism underlying the regulation of the activity of the TOFQ receptor kinases. TGF Beta could suppress the growth of breast cancer cells both in vivo and in vitro (1, 2, 3), and this function requires the expression of functional TGF Beta receptors (2, 3) and downstream signaling molecules (4). The TGF Beta family of cytokines has a wide range of biological functions including tumor suppression, extracellular matrix production, embryonic development, and regulation of differentiation(5). These functions are mediated by three specific surface receptors, Types I, II and III, all of which have been cloned (6, 7, 8, 9). The types I and II receptors for TGF Beta, T BetaRI and T BetaRll, are members of the first known receptor serine/threonine kinase family, and share 40% homology between their kinase domains. T BetaRll contains an extracellular domain which binds TGF beta, a transmembrane domain and a cytoplasmic domain with serine/threonine kinase activity. T BetaRI also has an extracellular domain even though it does not bind TGF Beta when expressed without T BetaRII. The cytoplasmic portion of T BetaRI contains a kinase domain and a membrane proximal region which contains a Oly-Ser rich sequence (OS box) that has been proposed to be important for the activation of T BetaRI (10). Both receptors exist normally as homodimers on the cell surface (11, 12) and their kinase activities are essential for signal transduction (6, 8, 9, 13). Binding of TGF Beta1 to T BetaRII induces the formation of a heteromeric complex of T BetaRI and T BetaRll (6, 8, 9, 13), which results in transphosphorylation of T BetaRI by the constitutively active TJ3Rll
Limitations: APPROVED FOR PUBLIC RELEASE
Description: Final rept. 5 Aug 96-31 Dec 97
Pages: 15
Report Date: DEC 1997
Contract Number: DAMD17-96-1-6286
Report Number: A905143
Keywords relating to this report:
ACTIVATION
BIOLOGY
BOXES
BREAST CANCER
CELLS(BIOLOGY)
CLONES
CONTROL
CYTOPLASM
EMBRYOS
FUNCTIONS
GROWTH(PHYSIOLOGY)
IN VITRO ANALYSIS
IN VIVO ANALYSIS
MOLECULES
NEOPLASMS
PHOSPHORUS TRANSFERASES
PHOSPHORYLATION
RANGE(EXTREMES)
RECEPTOR SITES(PHYSIOLOGY)
SENSE ORGANS
SIGNALS
SUBSTRATES
SUPPRESSION
SURFACES
TRANSDUCERS
www.stormingmedia.us/90/9051/A905143.html
======================================
It appears that these ......TGE-beta Receptor Kinases.......
have something to do with the communications between
these phosphorylation points in the body.
Kinase disease association:
www.cellsignal.com/reference/kinase_disease.html
How? mmmmmm will keep looking for the correct 30 kDa
skyship
certain areas of the body to others and appears that
the lesions and their contents signal to other lesions
and contents, fibers, neurons etc.
Here is a report that mentions transphophorylation.
===================
Analysis of the TGF-beta Receptor Signal Transduction Pathways and the TGE-beta Receptor Kinases
Authors: Kunxin Luo; WHITEHEAD INST FOR BIOMEDICAL RESEARCH CAMBRIDGE MA
Abstract: The principal goal of this project is to understand the transforming growth factor-Beta (TGF Beta) receptor signal transduction pathways and the molecular mechanism underlying the regulation of the activity of the TOFQ receptor kinases. TGF Beta could suppress the growth of breast cancer cells both in vivo and in vitro (1, 2, 3), and this function requires the expression of functional TGF Beta receptors (2, 3) and downstream signaling molecules (4). The TGF Beta family of cytokines has a wide range of biological functions including tumor suppression, extracellular matrix production, embryonic development, and regulation of differentiation(5). These functions are mediated by three specific surface receptors, Types I, II and III, all of which have been cloned (6, 7, 8, 9). The types I and II receptors for TGF Beta, T BetaRI and T BetaRll, are members of the first known receptor serine/threonine kinase family, and share 40% homology between their kinase domains. T BetaRll contains an extracellular domain which binds TGF beta, a transmembrane domain and a cytoplasmic domain with serine/threonine kinase activity. T BetaRI also has an extracellular domain even though it does not bind TGF Beta when expressed without T BetaRII. The cytoplasmic portion of T BetaRI contains a kinase domain and a membrane proximal region which contains a Oly-Ser rich sequence (OS box) that has been proposed to be important for the activation of T BetaRI (10). Both receptors exist normally as homodimers on the cell surface (11, 12) and their kinase activities are essential for signal transduction (6, 8, 9, 13). Binding of TGF Beta1 to T BetaRII induces the formation of a heteromeric complex of T BetaRI and T BetaRll (6, 8, 9, 13), which results in transphosphorylation of T BetaRI by the constitutively active TJ3Rll
Limitations: APPROVED FOR PUBLIC RELEASE
Description: Final rept. 5 Aug 96-31 Dec 97
Pages: 15
Report Date: DEC 1997
Contract Number: DAMD17-96-1-6286
Report Number: A905143
Keywords relating to this report:
ACTIVATION
BIOLOGY
BOXES
BREAST CANCER
CELLS(BIOLOGY)
CLONES
CONTROL
CYTOPLASM
EMBRYOS
FUNCTIONS
GROWTH(PHYSIOLOGY)
IN VITRO ANALYSIS
IN VIVO ANALYSIS
MOLECULES
NEOPLASMS
PHOSPHORUS TRANSFERASES
PHOSPHORYLATION
RANGE(EXTREMES)
RECEPTOR SITES(PHYSIOLOGY)
SENSE ORGANS
SIGNALS
SUBSTRATES
SUPPRESSION
SURFACES
TRANSDUCERS
www.stormingmedia.us/90/9051/A905143.html
======================================
It appears that these ......TGE-beta Receptor Kinases.......
have something to do with the communications between
these phosphorylation points in the body.
Kinase disease association:
www.cellsignal.com/reference/kinase_disease.html
How? mmmmmm will keep looking for the correct 30 kDa
skyship