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"Porphyria
Foreword
The idea to write started a research project. The investigation followed two TV programs concerning "Georges III madness" (shown on Channel 4) and "Kings and Queens of England" (shown on UK TV history channel). The first one showed the link between Georges III and the porphyry illness. It also showed how far the illness could be traced. The second TV programme explained that since Henry VI, madness has always been connected in some sort to the English crown. From these two programmes, I wondered if the madness of Georges III could be connected to the one of Henry VI.
The investigation has not been enjoyable. Most of the information was missing or hidden in a few books. Most of the contemporary biographies were written in view of flattering current monarch. For example, Henry VIII biography was written when James I had just been crown. As he was a heavy sponsor of the arts, most artists did not intend to disappoint him. The other source of misinformation was the misdiagnosed of the illness. For example, the illness could be either diagnosed as madness as for Georges III or as evidence of poisoning. It is until recently that porphyry has been diagnosed for Georges III.
The research went on for a while with mixing with a day job. The idea to turn the research into a book came from a mate. He suggested it when trying to write his on Signal Processing. However, as life is too short, I have decided to put only a brief summary on line and see what happens next.
This page subject is a bit controversial as it has never been developed. The origin of porphyry could also have impact on the current English royal family. If the origin is up to Henry VI, his mother, who married the Tudor dynasty founder, could have been the carrier. However, if the origin is somewhere else or earlier, the importance could even be greater. The longer the illness has been rooted in the family, bigger the risk is.
The conclusions could be debated for a while. Many of you may disagree with them. However, I invited you to read my research update and draw your own conclusions from the finding. This page is primarily (but not exclusively) intended for future researcher as if its conclusions are correct, the illness origin can be traced up to the Medieval."......
www.marc-rigot.co.uk/porphyria.php=================================
porphyrins nanotubes: the newest:
artificial life:
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"Chemical sensitivity amplification of porphyrins nanotubes
Nanotubular aggregation of ionic charged porphyrins elicits an amplification of the chemical sensitivity for the detection of chemical species in liquid and in air that can be adequately monitored by computer peripherals such as a webcam.
Porphyrins are a vast molecular family that play a key role in significant vital mechanisms such as the transport of oxygen in blood. In the past decade several authors demonstrated that the remarkable chemical richness of these molecules can be usefully exploited for chemical sensing and for odour recognition in artificial olfactory systems. "
Most of the remarkable sensing properties of metalloporphyrin have been studied in non-structured molecular films. Nonetheless, porphyrins chemical versatility also offers the possibility to drive self-assembled molecular aggregations to a large variety of ordered geometrical structures. As an example it is known that the aggregation of oppositely charged porphyrins can lead to the formation of self-assembled molecular nanotubes. Among the three-dimensional structures, nanotubes are particularly appealing for applications as chemical sensors, because of the potential inclusion of different guests inside the cavity or the induced modification of the skeletal interaction after analytes binding.
In a recent paper, published in Nanotechnology, the authors, following the original idea of Shelnutt, demonstrated that nanotubular aggregates of two charged porphyrins exhibit a sensitivity largely exceeding that of the individual constituents. The reason of the increased sensitivity may be likely found in an additional sensing mechanism related to the modulation of the amplitude of the forces that keep the supramolecular ensemble together.
Porphyrin nanotubes are characterized by specific optical properties in the visible range than can change upon the interaction with a guest molecule. In their recent Nanotechnology paper, the authors detected these changes with a simple platform based on the combination of a computer screen, programmed to display millions of colour combining wavelengths in the optical range, and a digital camera, decomposing the light into three broad channels. The authors demonstrated in the past that this arrangement, known as Computer Screen Photoassisted Technology, gives the possibility to perform optical characterizations allowing a simultaneous evaluation of absorbance and fluorescence of samples. Video capture and display are nowadays embedded in a steadily growing number of equipments (from portable computers to cellular phones) that are densely distributed over the whole planet. This fact makes this technique a privileged solution for ubiquitous sensing capability.
nanotechweb.org/cws/article/lab/37557metalloporphyrins:
holy maloney.......
www.scs.uiuc.edu/suslick/execsummporph.htmlEXECUTIVE SUMMARY:
PORPHYRIN AND METALLOPORPHYRIN CHEMISTRY
Kenneth S. Suslick
The research team led by Professor Suslick has been at the leading edge of research on synthetic metalloporphyrins for applications as synthetic analogs of heme proteins, shape selective oxidations, , and diverse materials chemistry applications including nanoporous network solids, non-linear optical materials, and selective sensors.
Synthetic metalloporphyrins:
metalloporphyrin heterdimer:
Control of Heme metabolism with metalloporphyrins:
www.jci.org/articles/view/112309/pdfskyship