Post by skyship on Mar 3, 2010 21:35:58 GMT -5
What does that mean?
Imaging structured space-time patterns of Ca2+ signals: essential information for decisions in cell division
STRUCTURE AND FUNCTION are interwoven within the fabric of essential cellular processes. The history of cell biology, especially throughout the past half century, has relied on integrated morphological and biochemical characterizations of specific processes. Many pioneers, Keith Porter being especially notable, have demonstrated that structures revealed through light and electron microscopy provided both a physical and conceptual scaffold on which biochemical and biophysical processes are conducted—a biochemical and biophysical cytology. Consideration of structure, however, is often limited to consideration of spatial dimensions of multi-molecular physical assemblies whose actions are rapid with respect to developmental processes. In this vein we can ask, "Is there is space-time structure to the regulatory biochemistry and transductions of dynamical cellular processes?" If such a space-time structure exists, then knowledge of its scale and bounds will be essential in establishing an understanding of fundamental biological processes.
To better understand the dynamics of these processes and their facilitating scaffold, we need to consider cellular processes in one temporal dimension as well as two or more spatial dimensions (i.e., observations along one temporal and two spatial dimensions of an optical section of a cell). Extending this notion of space-time structure to cellular signaling, we can apply mathematical approaches to learn if there is information content in those signals. If the cellular chemistry and physics of dynamical cellular processes does exists as a nonrandom structure, and there is inherent, nonrandom space-time structure to signals of dynamical cellular processes, then we may discover that it can lead to a more detailed understanding of that, and other related, processes.
www.fasebj.org/cgi/content/full/13/9002/S209
well, this is getting interesting..........
skyship
Imaging structured space-time patterns of Ca2+ signals: essential information for decisions in cell division
STRUCTURE AND FUNCTION are interwoven within the fabric of essential cellular processes. The history of cell biology, especially throughout the past half century, has relied on integrated morphological and biochemical characterizations of specific processes. Many pioneers, Keith Porter being especially notable, have demonstrated that structures revealed through light and electron microscopy provided both a physical and conceptual scaffold on which biochemical and biophysical processes are conducted—a biochemical and biophysical cytology. Consideration of structure, however, is often limited to consideration of spatial dimensions of multi-molecular physical assemblies whose actions are rapid with respect to developmental processes. In this vein we can ask, "Is there is space-time structure to the regulatory biochemistry and transductions of dynamical cellular processes?" If such a space-time structure exists, then knowledge of its scale and bounds will be essential in establishing an understanding of fundamental biological processes.
To better understand the dynamics of these processes and their facilitating scaffold, we need to consider cellular processes in one temporal dimension as well as two or more spatial dimensions (i.e., observations along one temporal and two spatial dimensions of an optical section of a cell). Extending this notion of space-time structure to cellular signaling, we can apply mathematical approaches to learn if there is information content in those signals. If the cellular chemistry and physics of dynamical cellular processes does exists as a nonrandom structure, and there is inherent, nonrandom space-time structure to signals of dynamical cellular processes, then we may discover that it can lead to a more detailed understanding of that, and other related, processes.
www.fasebj.org/cgi/content/full/13/9002/S209
well, this is getting interesting..........
skyship